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Contraindicated (1)pentobarbital will reduce the extent or effect of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will decrease the extent or outcome of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.

pentobarbital will minimize the level or influence of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital will lessen the extent or outcome of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. The efficacy of hormonal contraceptives may very well be diminished.

pentobarbital will minimize the level or effect of tamoxifen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will decrease the level or outcome of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Loss of, or lessened response to tofacitinib may well occur when coadministered with powerful CYP3A4 inducers

Monitor Closely (two)pentobarbital will minimize the extent or influence of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. If coadministration using a CYP3A4 inducer is critical, consider escalating oliceridine dose until finally steady drug effects are attained; check for signs of opioid withdrawal.

pentobarbital will reduce the level or impact of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will minimize the level or effect of oxybutynin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.

Sleeplessness could be the perception or complaint of insufficient or inadequate-quality sleep thanks to issues falling asleep; waking up routinely in the course of the night time with trouble returning to sleep; waking up much too early in the morning; or unrefreshing sleep.

pentobarbital will minimize the extent or influence of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital will minimize the here level or outcome of paclitaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.

Phenobarbital lowers the plasma amounts of dicumarol (name Formerly utilised: bishydroxycoumarin) and leads to a lower in anticoagulant action as calculated via the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in improved metabolism and reduced anticoagulant response of oral anticoagulants (e.